Functional and immunological peculiarities of peripheral nerve allografts
Kelly C.S.Roballo1
Jason P.Gigley2
Tyler A.Smith3
George D.Bittner4
Jared S.Bushman1
1.School of Pharmacy,University of Wyoming,Laramie,WY,USA2.Department of Molecular Biology,University of Wyoming,Laramie,WY,USA3.Department of Molecular Biosciences,University of Texas at Austin,Austin,TX,USA4.Department of Neuroscience,University of Texas at Austin,Austin,TX,USA
摘要：This review addresses the accumulating evidence that live (not decellularized) allogeneic peripheral nerves are functionally and immunologically peculiar in comparison withmany other transplanted allogeneic tissues. This is relevant because live peripheral nerve allografts are very effective at promoting recovery after segmental peripheral nerve injury via axonal regeneration and axon fusion. Understanding the immunological peculiarities of peripheral nerve allografts may also be of interest to the field of transplantation in general. Three topics are addressed: The first discusses peripheral nerve injury and the potential utility of peripheral nerve allografts for bridging segmental peripheral nerve defects via axon fusion and axon regeneration. The second reviews evidence that peripheral nerve allografts elicit a more gradual and less severe host immune response allowing for prolonged survival and function of allogeneic peripheral nerve cells and structures. Lastly, potential mechanisms that may account for the immunological differences of peripheral nerve allografts are discussed.
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论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 721-727 )
英文信息