Three-dimensional in vitro models of neuromuscular tissue
Paolo Raffa1
Maria Easler1
Anna Urciuolo2
1.Institute of Pediatric Research IRP,Padova,Italy2.Institute of Pediatric Research IRP,Padova,Italy;Molecular Medicine Department,University of Padova,Padova,Italy
摘要：Skeletal muscle is a dynamic tissue in which homeostasis and function are guaranteedby a very defined three-dimensional organization of myofibers in respect to other non-muscular components, including the extracellular matrix and the nervous network. In particular, communication between myofibers and the nervous system is essential for the overall correct development and function of the skeletal muscle. A wide range of chronic, acute and genetic-based human pathologies that lead to the alteration of muscle function are associated with modified preservation of the fine interaction between motor neurons and myofibers at the neuromuscular junction. Recent advancements in the development of in vitro models for human skeletal muscle have shown that three-dimensionality and integration of multiple cell types are both key parameters required to unveil pathophysiological relevant phenotypes. Here, we describe recent achievement reached in skeletal muscle modeling which used biomaterials for the generation of three-dimensional constructs of myotubes integrated with motor neurons.
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论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 759-766 )
英文信息