A simple human cell model for TAU trafficking and tauopathy-related TAU pathology
Michael Bell1
Hans Zempel2
1.Institute of Human Genetics,Faculty of Medicine and University Hospital Cologne,University of Cologne2.Center for Molecular Medicine Cologne(CMMC),University of Cologne,Cologne,Germany
摘要：The microtubule (MT)-associated protein TAU is highly abundant in the axon of human brain neurons, where it binds to and stabilizes MT filaments. Thereby, TAU regulates the dynamic (dis)assembly of MT strands and is involved in a wide range of neuronal functions. In Alzheimer's disease (AD) and other tauopathies, TAU is missorted into the somatodendritic compartment. TAU missorting is accompanied by (or leads to) abnormal TAU phosphorylation, MT destabilization, and loss of dendritic spines and mitochondria, eventually resulting in TAU aggregation, neuronal dysfunction and cell death (Arendt et al., 2016). Strikingly, the mechanisms of TAU sorting, and the detrimental cascade upon its failure, are still not fully understood.
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论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 770-772 )