Non-invasive gene delivery across the blood-brain barrier: present and future perspectives
Seigo Kimura
Hideyoshi Harashima
Laboratory for Molecular Design of Pharmaceutics,Faculty of Pharmaceutical Sciences,Hokkaido University,Sapporo,Japan;Laboratory of Innovative Nanomedicine,Faculty of Pharmaceutical Sciences,Hokkaido University,Sapporo,Japan
摘要：The aging of society has arrived, and is accompanied by an increase in the absolute numbers of patients with neurological disorders, such as Alzheimer's and Parkinson's diseases (Feigin et al., 2020). Such diseases, particularly Alzheimer's disease and other forms of dementia, affect not only the patients themselves, but also the people around them, including family members and care givers. As a result, such neurological disorders are thought to carry a larger social burden compared to other diseases. The most critical point in the current situation is that there is no effective treatment despite the fact that the number of patients increase with the aging of the population. Gene therapy has great promise for the treatment of neurological disorders (Sun and Roy, 2021), but delivering therapeutic genes is a major impediment for the success of gene therapy.
机标关键词：
论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 785-787 )