Axon regeneration: membrane expansion and lipidomics
Sean Meehan
Sanjoy K.Bhattacharya
Graduate Program in Molecular and CellularPharmacology,Miami Integrative Metabolomics Research Center,Bascom Palmer Eye Institute,University of Miami,Miami,FL,USA
摘要：Axon regeneration requires protein synthesis and membrane expansion. The presence of granular material was discovered in the perikaryon of neurons but not axons using Nissl staining (Gomes, 2019). This is one of the characteristic features of neurons and we now know that RNA content of the granular material stains with Nissl stain. Although no Nissl granules are present in axons, mRNA can be shuttled to distal axons for local protein synthesis. Axonal protein synthesis only makes up a small portion as the majority occurs in the perikaryon. The required membrane expansion and protein synthesis machinery are still present in the adult central nervous system (CNS) axon.
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论文发表日期：2022-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 989-990 )