Activity-dependent remodeling of genome architecture in engram cells facilitates memory formation and recall
Asaf Marco
Neuro-Epigenetics Laboratory,the Robert H.Smith Faculty of Food,Environment and Agriculture,the Hebrew University of Jerusalem,Rehovol Campus,Israel
摘要：The formation and preservation of long-term memories critically depend upon coordinated activity of neuronal circuits, intracellular signaling cascades and synaptic remodeling (Josselyn et al., 2015). These essential processes occur in specific cell populations known as the engram ensemble (Josselyn et al., 2015). The current model for engram formation suggests that an experience activates a sub-population of neurons that can be measured by the expression of immediate early genes (IEG), such as Arc (activity regulated cytoskeleton associated protein, Arg3.1) or cFos (Fos Proto-Oncogene, AP-1 transcription factor subunit).
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论文发表日期：2022-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 991-993 )