Metabolic reprogramming of glial cells as a new target for central nervous system axon regeneration
Erin L.Walden
Shuxin Li
Shriners Hospitals Pediatric Research Center,Department of Neural Sciences,Lewis Katz School of Medicine at Temple University,Philadelphia,PA,USA
摘要：After central nervous system (CNS) injury, severed axons fail to regenerate and their disconnections to the original targets result in permanent functional deficits in patients (Mahar and Cavalli, 2018). Both the diminished intrinsic regenerative capacity of mature neurons and the inhibitory CNS milieu contribute to the regenerative failure following CNS injury. Glial cells have important physiological functions, including maintaining homeostasis, supporting and protecting neurons, regulating neuronal activities, and forming myelin (Gaudet and Fonken, 2018). In response to CNS injury, reactive glial cells shift their phenotype and activities and contribute to scar formation.
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论文发表日期：2022-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 997-998 )