Self-renewal of peripheral nerve resident macrophage: does it represent a unique activation status?
Maricris Bautista
Anand Krishnan
Department of Anatomy,Physiology,andPharmacology,College of Medicine,University of Saskatchewan,Saskatoon,SK,Canada;Cameco MS Neuroscience Research Centre(CMSNRC),University of Saskatchewan,Saskatoon,SK,Canada
摘要：Macrophages are immune cells of myeloid origin and are present in almost all tissues. They perform a wide variety of functions contributing to tissue development, homeostasis, pathogenesis, and repair (Wynn et al., 2013). Strikingly, macrophages residing at different tissues, and at different compartments of an individual tissue, demonstrate enormously diverse molecular characteristics (Gordon and Taylor, 2005). Querying this exceptional molecular heterogeneity challenged the long-standing theory that adult tissue macrophages derive solely from circulating monocytes. Indeed, lineage tracing and fate mapping studies using chimeric and cre-floxed animal models, followed by RNA-sequencing, convincingly demonstrated that tissue resident macrophages also consist of a pool that originates from yolk-sac progenitor cells (YPC) (Ginhoux and Guilliams, 2016; De Schepper et al., 2018).
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论文发表日期：2022-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 999-1000 )