Investigating the role of Ca2+/ calmodulin-dependent protein kinase Ⅱ in the survival of retinal ganglion cells
Xinzheng Guo
Bo Chen
Departments of Ophthalmology and Neuroscience,Icahn School of Medicine at Mount Sinai,NewYork,NY,USA
摘要：Retinal ganglion cells (RGCs) are the sole output neurons of the retina that project long axons and transmit visual information to the brain. The degeneration of RGCs leads to irreversible vision loss in a variety of pathological states, including excitotoxicity, traumatic nerve injury, and glaucoma. However, an unmet clinical challenge is the lack of effective neuroprotective approaches to protect RGCs and thus preserve their function, necessitating extensive investigation of pro-survival genes in basic and translational research. Here, we first briefly describe widely used experimental models of RGC degeneration and methods for evaluating gene function in RGC survival, and then share our thoughts on the role of Ca2+/calmodulin-dependent protein kinase Ⅱ(CaMKII) in regulating the survival of RGCs after excitotoxic injury.
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论文发表日期：2022-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1001-1002 )