Iron, the endolysosomal system and neuroinflammation: a matter of balance
Daniel A.Bórquez1
Pamela J.Urrutia2
Marco T.Nú?ez2
1.Center for Biomedical Research,Faculty ofMedicine,Universidad Diego Portales,Santiago,Chile2.Department of Biology,Faculty of Sciences,Universidad de Chile,Santiago,Chile
摘要：Iron accumulation and neuroinflammation are cardinal features of many neurodegenerative diseases (Urrutia et al., 2021). However, the hierarchy in the pathogenic mechanisms and the molecular connections between these processes are still obscure. In this perspective, we will discuss current evidence showing that aging, the main risk factor for neurodegenerative diseases, negatively impacts lysosomal function by triggering a paradoxical condition of iron accumulation accompanied by functional iron deficiency. This condition is self-sustaining in the neuroinflammatory process.
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论文发表日期：2022-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1003-1004 )