All roads lead to Rome—a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer's disease
Yi-Yao Liang1
Li-Dan Zhang1
Xi Luo1
Li-Li Wu2
Zhao-Wei Chen3
Guang-Hao Wei3
Kai-Qing Zhang3
Ze-An Du4
Ren-Zhi Li5
Kwok-Fai So6
Ang Li7
1.Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China;Key Laboratory of CNS Regeneration(Jinan University),Ministry of Education,Guangzhou,Guangdong Province,China2.Department of Medical Ultrasonics,Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong Province,China;Guangdong Key Laboratory of Liver Disease Research,Sun Yat-sen University,Guangzhou,Guangdong Province,China3.Department of Clinical Medicine,School of Medicine,Jinan University,Guangzhou,Guangdong Province,China4.Department of Clinical Medicine,International School,Jinan University,Guangzhou,Guangdong Province,China5.International Department of the Affiliated High School of South China Normal University,Guangzhou,Guangdong Province,China6.Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China;Key Laboratory of CNS Regeneration(Jinan University),Ministry of Education,Guangzhou,Guangdong Province,China;Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China7.Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China;Key Laboratory of CNS Regeneration(Jinan University),Ministry of Education,Guangzhou,Guangdong Province,China;Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China
摘要：Age-related neurodegenerative disorders such as Alzheimer's disease(AD)have become a critical public health issue due to the significantly extended human lifespan,leading to considerable economic and social burdens.Traditional therapies for AD such as medicine and surgery remain ineffective,impractical,and expensive.Many studies have shown that a variety of bioactive substances released by physical exercise(called"exerkines")help to maintain and improve the normal functions of the brain in terms of cognition,emotion,and psychomotor coordination.Increasing evidence suggests that exerkines may exert beneficial effects in AD as well.This review summarizes the neuroprotective effects of exerkines in AD,focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise.The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages,genders,and health conditions.
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论文发表日期：2022-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 1210-1227 )
英文信息