Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage
Junfan Chen1
Zhiyuan Vera Zheng2
Gang Lu3
Wai Yee Chan4
Yisen Zhang5
George Kwok Chu Wong1
1.Division of Neurosurgery,Department of Surgery,The Chinese University of Hong Kong,Hong Kong Special Administrative Region,China2.Division of Neurosurgery,Department of Surgery,The Chinese University of Hong Kong,Hong Kong Special Administrative Region,China;Departmentof Neurosurgery,Hainan Branch of Chinese People's Liberation Army General Hospital,Sanya,Hainan Province,China3.CUHK-SDU Joint Laboratory on Reproductive Genetics,School of Biomedical Sciences,the Chinese University of Hong Kong,Hong Kong Special Administrative Region,China;Bioinformatics Unit,SDIVF R&D Centre,Hong Kong Science and Technology Parks,Hong Kong Special Administrative Region,China4.CUHK-SDU Joint Laboratory on Reproductive Genetics,School of Biomedical Sciences,the Chinese University of Hong Kong,Hong Kong Special Administrative Region,China5.Department of InterventionalNeuroradiology,Beijing Neurosurgical Institute,Beijing Tiantan Hospital,Capital Medical University,Beijing,China
摘要：Subarachnoid hemorrhage is a devastating disease with significant mortality and morbidity, despite advances in treating cerebral aneurysms. There has been recent progress in the intensive care management and monitoring of patients with subarachnoid hemorrhage, but the results remain unsatisfactory. Microglia, the resident immune cells of the brain, are increasingly recognized as playing a significant role in neurological diseases, including subarachnoid hemorrhage. In early brain injury following subarachnoid hemorrhage, microglial activation and neuroinflammation have been implicated in the development of disease complications and recovery. To understand the disease processes following subarachnoid hemorrhage, it is important to focus on the modulators of microglial activation and the pro-inflammatory/anti-inflammatory cytokines and chemokines. In this review, we summarize research on the modulators of microglia-mediated inflammation in subarachnoid hemorrhage, including transcriptome changes and the neuroinflammatory signaling pathways. We also describe the latest developments in single-cell transcriptomics for microglia and summarize advances that have been made in the transcriptome- based classification of microglia and the implications for microglial activation and neuroinflammation.
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论文发表日期：2022-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1404-1411 )
英文信息