Quo vadis? Bioengineered polysaccharide-based hydrogel scaffolds for damaged central nervous system recovery and regeneration
Isadora C.Carvalho
Herman S.Mansur
Center of Nanoscience,Nanotechnologyand Innovation-CeNano2I,Department of Metallurgical and Materials Engineering,Federal University of Minas Gerais,Belo Horizonte,MG,Brazil
摘要：Impairments in the central nervous system (CNS) are a prevalent cause of life-long disabilities worldwide, representing serious health, social, and economic concerns (Doblado et al., 2021). During the last decades, with the population eldering and the increase in the life span, we have experienced an increase in CNS-related disorders, like stroke and neurodegenerative diseases (Jarrin et al., 2021). Paralysis, cognitive function, and sensory losses (Jensen et al., 2020) are among the most predominant outcomes. Regrettably, there is still no effective therapy for CNS repair and regeneration (CNSRR), where most of the current therapeutics can only prevent continued damage in the affected area (Ali and Bhuiyan, 2021). The presence of the blood-brain barrier restricts the permeation of drugs through the circulation, and the difficulty of accessing the damaged regions, which usually demand invasive surgeries, compromise even more the effectiveness of the available treatments (Ojeda-Hernández et al., 2020). Thus, there is an urge to develop an effective therapy for CNSRR. Hopefully, a multidisciplinary strategy has been adopted for designing sophisticated multifunctional platforms based on nature-sourced materials capable of influencing cell fate, delivering therapeutics for the damaged area in a sustained manner, and supporting the adjacent brain parenchyma aiming at CNSRR: the polysaccharides. Here, we do not cover the overall properties of polysaccharide-based materials. Hence, we emphatically recommend the readers resort to state-of-the-art works referenced throughout this paper for further comprehension of the theme (Carvalho et al., 2021; Doblado et al., 2021; Tupone et al., 2021).
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论文发表日期：2022-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1478-1480 )