The role of lysosomes in alpha-synucleinopathies: a focus on glial cells
Denise Balta
Friederike Zunke
Department of Molecular Neurology,University Hospital Erlangen,Friedrich-Alexander-Universit?t Erlangen-Nürnberg,Erlangen,Germany
摘要：Lysosomes are the major degradative compartments within eukaryotic cells. Besides their role in the degradation and recycling of intra- and extracellular molecules, they further mediate important biological processes, such as immune signaling and perpetuation of nutrient- and energy homeostasis. Impairment of lysosomal function triggers the accumulation of catabolic products within the organelle resulting in lysosomal storage disorders (LSDs). Interestingly, clinical, molecular, and genetic studies further indicate a strong link between lysosomal dysfunction and neurodegenerative disorders, including Parkinson's disease (PD). Because of the association of lysosomal dysfunction and protein aggregation of α-synuclein (α-Syn) in PD or multiple system atrophy (MSA), the role of lysosomal pathways has been a matter of recent studies, mostly focusing on neuronal cells. Although it is known that glial cells play an important role in disease pathology of PD and MSA, only few studies on the lysosomal pathways, within glial cells have been carried out. Hence, a better understanding of lysosomal function in glia is needed to elucidate disease pathogenesis and to search for novel therapeutic approaches.
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论文发表日期：2022-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1486-1488 )