Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases
Fatemeh Zahedipour1
Seyede Atefe Hosseini1
Neil C.Henney2
George E.Barreto3
Amirhossein Sahebkar4
1.Department of Medical Biotechnology,School of Medicine,Mashhad University of Medical Sciences,Mashhad,Iran;Student Research Committee,Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad,Iran2.Pharmacy&Biomolecular Sciences,Liverpool John Moores University,Liverpool,UK3.Department of Biological Sciences,University of Limerick,Limerick,Ireland;Health Research Institute,University of Limerick,Limerick,Ireland4.Applied Biomedical Research Center,Mashhad University of Medical Sciences,Mashhad,Iran;Biotechnology Research Center,Pharmaceutical Technology Institute,Mashhad University of Medical Sciences,Mashhad,Iran;Polish Mother's Memorial Hospital Research Institute(PMMHRI),Lodz,Poland;School of Pharmacy,Mashhad University of Medical Sciences,Mashhad,Iran
摘要：Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders. Tumor necrosis factor alpha has been reported to play a major role in the central nervous system in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and many other neurodegenerative diseases. Therefore, a potent proinflammatory/proapoptotic tumor necrosis factor alpha could be a strong candidate for targeted therapy. Plant derivatives have now become promising candidates as therapeutic agents because of their antioxidant and chemical characteristics, and anti-inflammatory features. Recently, phytochemicals including flavonoids, terpenoids, alkaloids, and lignans have generated interest as tumor necrosis factor alpha inhibitor candidates for a number of diseases involving inflammation within the nervous system. In this review, we discuss how phytochemicals as tumor necrosis factor alpha inhibitors are a therapeutic strategy targeting neurodegeneration.
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论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1675-1684 )
英文信息