The brain as a source and a target of prolactin in mammals
Ana R.Costa-Brito1
Isabel Gon?alves2
Cecília R.A.Santos2
1.CICS-UBI-Health Sciences Research Centre,Universidade da Beira Interior,Covilh?,Portugal2.CICS-UBI-Health Sciences Research Centre,Universidade da Beira Interior,Covilh?,Portugal;C4-UBI-Cloud Computing Competence Centre,Universidade da Beira Interior,Covilh?,Portugal
摘要：Prolactin is a polypeptide hormone associated with an extensive variety of biological functions. Among the roles of prolactin in vertebrates, some were preserved throughout evolution. This is the case of its function in the brain, where prolactin receptors, are expressed in different structures of the central nervous system. In the brain, prolactin actions are principally associated with reproduction and parental behavior, and involves the modulation of adult neurogenesis, neuroprotection, and neuroplasticity, especially during pregnancy, thereby preparing the brain to parenthood. Prolactin is mainly produced by specialized cells in the anterior pituitary gland. However, during vertebrate evolution many other extrapituitary tissues do also produce prolactin, like the immune system, endothelial cells, reproductive structures and in several regions of the brain. This review summarizes the relevance of prolactin for brain function, the sources of prolactin in the central nervous system, as well as its local production and secretion. A highlight on the impact of prolactin in human neurological diseases is also provided.
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论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1695-1702 )
英文信息