Myeloperoxidase: a new target for the treatment of stroke?
Yun-Chang Wang1
Yu-Bao Lu2
Xiao-Lan Huang3
Yong-Feng Lao4
Lu Zhang4
Jun Yang4
Mei Shi4
Hai-Long Ma4
Ya-Wen Pan5
Yi-Nian Zhang5
1.The Second Clinical Medical School,Lanzhou University,Lanzhou,Gansu Province,China;Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou,Gansu Province,China;Xiangya Hospital,Central South University,Changsha,Hunan Province,China2.The Second Clinical Medical School,Lanzhou University,Lanzhou,Gansu Province,China;Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou,Gansu Province,China;Department of Spine Surgery,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China3.University of Chinese Academy of Sciences,Beijing,China4.The Second Clinical Medical School,Lanzhou University,Lanzhou,Gansu Province,China5.The Second Clinical Medical School,Lanzhou University,Lanzhou,Gansu Province,China;Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou,Gansu Province,China
摘要：Myeloperoxidase is an important inflammatory factor in the myeloid system, primarily expressed in neutrophils and microglia. Myeloperoxidase and its active products participate in the occurrence and development of hemorrhagic and ischemic stroke, including damage to the blood-brain barrier and brain. As a specific inflammatory marker, myeloperoxidase can be used in the evaluation of vascular disease occurrence and development in stroke, and a large amount of experimental and clinical data has indicated that the inhibition or lack of myeloperoxidase has positive impacts on stroke prognosis. Many studies have also shown that there is a correlation between the overexpression of myeloperoxidase and the risk of stroke. The occurrence of stroke not only refers to the first occurrence but also includes recurrence. Therefore, myeloperoxidase is significant for the clinical evaluation and prognosis of stroke. This paper reviews the potential role played by myeloperoxidase in the development of vascular injury and secondary brain injury after stroke and explores the effects of inhibiting myeloperoxidase on stroke prognosis. This paper also analyzes the significance of myeloperoxidase etiology in the occurrence and development of stroke and discusses whether myeloperoxidase can be used as a target for the treatment and prediction of stroke.
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论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1711-1716 )
英文信息