Intranasal neprilysin rapidly eliminates amyloid-beta plaques,but causes plaque compensations:the explanation why the amyloid-beta cascade may fail?
Christian Humpel
Laboratory of Psychiatry and Experimental Alzheimer's Research,Medical University of Innsbruck,Innsbruck,Austria
摘要：Neurodegenerative brain disorders are a major burden in our society,such as Alzheimer's disease.In order to repair or prevent such diseases,drugs are designed which enter the brain,but the blood-brain barrier limits their entry and the search for alternative pathways is important.Recently,we reported that intranasal delivery of the amyloid-beta degrading enzyme neprilysin eliminated amyloid-beta plaques in transgenic Alzheimer's disease mice.This review describes the anatomical structure of the intranasal pathway,explains the intranasal delivery of pure neprilysin,cell-loaded neprilysin (platelets) and collagen-embedded neprilysin to destruct amyloid-beta plaques in Alzheimer's disease in transgenic APP_SweDI mice and hypothesizes why this may cause compensation and why the amyloid-beta cascade hypothesis may fail.
机标关键词：
论文发表日期：2022-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1881-1884 )
英文信息