Repurposed anti-cancer epidermal growth factor receptor inhibitors:mechanisms of neuroprotective effects in Alzheimer's disease
Heba M.Mansour1
Hala M.Fawzy1
Aiman S.EI-Khatib2
Mahmoud M.Khattab2
1.Department of Pharmacology,Egyptian Drug Authority,EDA,formerly NODCAR,Giza,Egypt2.Department of Pharmacology and Toxicology,Faculty of Pharmacy,Cairo University,Cairo,Egypt
摘要：Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer's disease.Recent studies have shown the beneficial effects of epidermal growth factor receptor inhibitors on the enhancement of behavioral and pathological sequelae in Alzheimer's disease.Despite the promising effects of epidermal growth factor receptor inhibitors in Alzheimer's disease,there is no irrefutable neuroprotective evidence in well-established animal models using epidermal growth factor receptor inhibitors due to many un-explored downstream signaling pathways.This caused controversy about the potential involvement of epidermal growth factor receptor inhibitors in any prospective clinical trial.In this review,the mystery beyond the under-investigation of epidermal growth factor receptor in Alzheimer's disease will be discussed.Furthermore,their molecular mechanisms in neurodegeneration will be explained.Also,we will shed light on SARS-COVlD-19 induced neurological manifestations mediated by epidermal growth factor modulation.Finally,we will discuss future perspectives and under-examined epidermal growth factor receptor downstream signaling pathways that warrant more exploration.We conclude that epidermal growth factor receptor inhibitors are novel effective therapeutic approaches that require further research in attempts to be repositioned in the delay of Alzheimer's disease progression.
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论文发表日期：2022-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1913-1918 )
英文信息