Alerting effects of light in healthy individuals:a systematic review and meta-analysis
Yi-Man Mu1
Xiao-Dan Huang2
Sui Zhu1
Zheng-Fang Hu2
Kwok-Fai So3
Chao-Ran Ren3
Qian Tao4
1.Department of Public Health and Preventive Medicine,School of Basic Medicine,Jinan University,Guangzhou,Guangdong Province,China;Division of Medical Psychology and Behavior Science,School of Basic Medicine,Jinan University,Guangzhou,Guangdong Province,China2.Guangdong-Hongkong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China3.Guangdong-Hongkong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China;Guangzhou Regenerative Medicine and Health Guangdong Laboratory,Guangzhou,Guangdong Province,China;Center for Brain Science and Brain-Inspired Intelligence,Guangdong-Hong Kong-Macao Greater Bay Area,Guangzhou,Guangdong Province,China;Neuroscience and Neurorehabilitation Institute,University of Health and Rehabilitation Science,Qingdao,Shandong Province,China;Co-innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China4.Department of Public Health and Preventive Medicine,School of Basic Medicine,Jinan University,Guangzhou,Guangdong Province,China;Division of Medical Psychology and Behavior Science,School of Basic Medicine,Jinan University,Guangzhou,Guangdong Province,China;Center for Brain Science and Brain-Inspired Intelligence,Guangdong-Hong Kong-Macao Greater Bay Area,Guangzhou,Guangdong Province,China;Neuroscience and Neurorehabilitation Institute,University of Health and Rehabilitation Science,Qingdao,Shandong Province,China
摘要：Light plays an essential role in psychobiological and psychophysiological processes,such as alertness.The alerting effect is influenced by light characteristics and the timing of interventions.This meta-analysis is the first to systematically review the effect of light intervention on alertness and to discuss the optimal protocol for light intervention.In this meta-analysis,registered at PROSPERO (Registration ID:CRD42020181485),we conducted a systematic search of the Web of Science,PubMed,and PsyclNFO databases for studies published in English prior to August 2021.The outcomes included both subjective and objective alertness.Subgroup analyses considered a variety of factors,such as wavelength,correlated color temperature (CCT),light illuminance,and timing of interventions (daytime,night-time,or all day).Twenty-seven crossover studies and two parallel-group studies were included in this meta-analysis,with a total of 1210 healthy participants (636 (52％)male,mean age 25.62 years).The results revealed that light intervention had a positive effect on both subjective alertness (standardized mean difference (SMD) =-0.28,95％confidence interval (CI):-0.49 to-0.06,P =0.01) and objective alertness in healthY subjects (SMD =-0.34,95％ CI:-0.68 to-0.01,P =0.04).The subgroup analysis revealed that cold light was better than warm light in improving subjective alertness (SMD =-0.37,95％ CI:-0.65 to-0.10,P =0.007,I2 =26％) and objective alertness (SMD =-0.36,95％ CI:-0.66 to-0.07,P =0.02,I2 =0).Both daytime (SMD =-0.22,95％ CI:-0.37 to-0.07,P =0.005,I2 =74％) and night-time (SMD =-0.32,95％ CI:-0.61 to-0.02,P =0.04,I2 =0) light exposure improved subjective alertness.The results of this meta-analysis and systematic review indicate that light exposure is associated with significant improvement in subjective and objective alertness.In addition,light exposure with a higher CCT was more effective in improving alertness than light exposure with a lower CCT.Our results also suggest that both daytime and night-time light exposure can improve subjective alertness.
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论文发表日期：2022-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1929-1936 )
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