Bone marrow-derived mononuclear stem cells in the treatment of retinal degenerations
Diego García-Ayuso1
Johnny Di Pierdomenico1
David García-Bernal2
Manuel Vidal-Sanz1
María P.Villegas-Pérez1
1.Departamento de Oftalmología,Facultad de Medicina,Universidad de Murcia,Campus de Ciencias de la salud,Murcia,Spain;Instituto Murciano de Investigación Biosanitaria Hospital Virgen de la Arrixaca (IMIB-Virgen de la Arrixaca),Murcia,Spain2.Instituto Murciano de Investigación Biosanitaria Hospital Virgen de la Arrixaca (IMIB-Virgen de la Arrixaca),Murcia,Spain;Servicio de Hematología,Hospital Clínico Universitario Virgen de la Arrixaca,Murcia,Spain
摘要：Retinal degenerative diseases affecting the outer retina in its many forms (inherited,acquired or induced) are characterized by photoreceptor loss,and represent currently a leading cause of irreversible vision loss in the world.At present,there are very few treatments capable of preventing,recovering or reversing photoreceptor degeneration or the secondary retinal remodeling,which follows photoreceptor loss and can also cause the death of other retinal cells.Thus,these diseases are nowadays one of the greatest challenges in the field of ophthalmological research.Bone marrow derived-mononuclear stem cell transplantation has shown promising results for the treatment of photoreceptor degenerations.These ceils may have the potential to slow down photoreceptor loss,and therefore should be applied in the early stages of photoreceptor degenerations.Furthermore,because of their possible paracrine effects,they may have a wide range of clinical applications,since they can potentially impact on several retinal cell types at once and photoreceptor degenerations can involve different cells and/or begin in one cell type and then affect adjacent cells.The intraocular injection of bone marrow derived-mononuclear stem cells also enhances the outcomes of other treatments aimed to protect photoreceptors.Therefore,it is likely that future investigations may combine bone marrow derived-mononuclear stem cell therapy with other systemic or intraocular treatments to obtain greater therapeutic effects in degenerative retinal diseases.
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论文发表日期：2022-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1937-1944 )
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