Inhibition of central axon regeneration:perspective from chondroitin sulfate proteoglycans in lamprey spinal cord injury
Jianli Hu1
Li-Qing Jin1
Michael E.Selzer2
1.Shriners Hospitals Pediatric Research Center(Center for Neural Repair and Rehabilitation),Lewis Katz School of Medicine at Temple University,Philadelphia,PA,USA2.Shriners Hospitals Pediatric Research Center(Center for Neural Repair and Rehabilitation),Lewis Katz School of Medicine at Temple University,Philadelphia,PA,USA;Department of Neurology,Lewis Katz School of Medicine at Temple University,Philadelphia,PA,USA
摘要：Background:Failure of axon regeneration after spinal cord injury (SCI) underlies the paralysis that so profoundly affects patients' quality of life.Many factors are involved in the regeneration failure.Chondroitin sulfate proteoglycans (CSPGs),normal constituents of the perineuronal nets in central nervous system (CNS),are secreted at the injury site and initially were thought to act as a purely physical barrien In the past decade,the receptor-like protein tyrosine phosphatases,protein tyrosine phosphatase sigma (PTPσ),and leukocyte common antigen-related phosphatase (LAR),have been identified as transmembrane receptors for CSPGs.The two receptors for myelin-associated growth inhibitors,Nogo receptors 1 and 3 (NgR1 and NgR3) also have been found to bind with CSPGs (Sharma et al.,2012).These findings suggest that CSPGs inhibit regeneration by interacting with these receptors,initiating downstream inhibitory signaling (Figure 1).
机标关键词：
论文发表日期：2022-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1955-1956 )