Neuronal circuitry reconstruction after stem cell therapy in damaged brain
Daniel Tornero
Department of Biomedical Sciences,Institute of Neuroscience and Production and Validation Center of Advanced Therapies (Creatio),University of Barcelona;August Pi I Sunyer Biomedical Research Institute (IDIBAPS);Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED),Barcelona,Spain
摘要：Transplantation of neuronal precursors derived from human pluripotent stem cells is a promising therapy for the treatment of neurological disorders associated with neuronal loss,such us neurodegenerative diseases,brain trauma and stroke.The functional integration of grafted neurons differentiated from stem cells into the host injured neuronal circuitry has been a major challenge in cell therapy strategies for brain repair (Palma-Tortosa et al.,2021).Even though other cell types or mechanisms may provide modest clinical improvements,neuronal replacement and reconstruction of the damaged area are crucial for an optimal and long-term recovery.
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论文发表日期：2022-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1959-1960 )