Graphene and graphene-based materials in axonal repair of spinal cord injury
Shi-Xin Wang1
Yu-Bao Lu2
Xue-Xi Wang3
Yan Wang1
Yu-Jun Song1
Xiao Wang1
Munkhtuya Nyamgerelt1
1.School of Basic Medical Sciences,Lanzhou University,Lanzhou,Gansu Province,China2.The Second Clinical Medical College,Lanzhou University,Lanzhou,Gansu Province,China;Department of Spine Surgery,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China3.School of Basic Medical Sciences,Lanzhou University,Lanzhou,Gansu Province,China;Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province,Lanzhou,Gansu Province,China
摘要：Graphene and graphene-based materials have the ability to induce stem cells to differentiate into neurons, which is necessary to overcome the current problems faced in the clinical treatment of spinal cord injury. This review summarizes the advantages of graphene and graphene-based materials (in particular, composite materials) in axonal repair after spinal cord injury. These materials have good histocompatibility, and mechanical and adsorption properties that can be targeted to improve the environment of axonal regeneration. They also have good conductivity, which allows them to make full use of electrical nerve signal stimulation in spinal cord tissue to promote axonal regeneration. Furthermore, they can be used as carriers of seed cells, trophic factors, and drugs in nerve tissue engineering scaffolds to provide a basis for constructing a local microenvironment after spinal cord injury. However, to achieve clinical adoption of graphene and graphene-based materials for the repair of spinal cord injury, further research is needed to reduce their toxicity.
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论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2117-2125 )
英文信息