WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder
Alexandre Vallée1
Yves Lecarpentier2
Jean-No?l Vallée3
1.Department of Clinical Research and Innovation(DRCI),Foch Hospital,Suresnes,France2.Centre de Recherche Clinique,Grand H?pital de l'Est Francilien(GHEF),Meaux,France3.Laboratoire de Mathématiques et Applications(LMA),Universitéde Poitiers,Poitiers,France;Centre Hospitalier Universitaire(CHU)Amiens Picardie,UniversitéPicardie Jules Verne(UPJV),Amiens,France
摘要：The neuropsychiatric disease named obsessive-compulsive disorder is composed by obsessions and/or compulsions. Obsessive-compulsive disorder etiologies are undefined. However, numerous mechanisms in several localizations are implicated. Some studies showed that both glutamate, inflammatory factors and oxidative stress could have main functions in obsessive-compulsive disorder. Glycogen synthase kinase-3β, the major negative controller of the WNT/β-catenin pathway is upregulated in obsessive-compulsive disorder. In obsessive-compulsive disorder, some studies presented the actions of the different circadian clock genes. WNT/β-catenin pathway and circadian clock genes appear to be intricate. Thus, this review focuses on the interaction between circadian clock genes and the WNT/β-catenin pathway in obsessive-compulsive disorder.
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论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 2126-2130 )
英文信息