Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
Wei Zheng So1
Natalie Shi Qi Wong1
Hong Chang Tan2
Molly Tzu Yu Lin3
Isabelle Xin Yu Lee3
Jodhbir S.Mehta4
Yu-Chi Liu5
1.Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore;Singapore Eye Research Institute,Singapore,Singapore2.Department of Endocrinology, Singapore General Hospital,Singapore,Singapore3.Singapore Eye Research Institute,Singapore,Singapore4.Singapore Eye Research Institute,Singapore,Singapore;Department of Cornea and External Eye Disease,Singapore National Eye Centre,Singapore,Singapore;Ophthalmology and Visual Sciences Academic Clinical Program,Duke-NUS Medical School,Singapore,Singapore5.Singapore Eye Research Institute,Singapore,Singapore;Department of Cornea and External Eye Disease,Singapore National Eye Centre,Singapore,Singapore;Ophthalmology and Visual Sciences Academic Clinical Program,Duke-NUS Medical School,Singapore,Singapore;
摘要：Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus, affecting nerves in all parts of the body including corneal nerves and peripheral nervous system, leading to diabetic corneal neuropathy and diabetic peripheral neuropathy, respectively. Diabetic peripheral neuropathy is diagnosed in clinical practice using electrophysiological nerve conduction studies, clinical scoring, and skin biopsies. However, these diagnostic methods have limited sensitivity in detecting small- fiber disease, hence they do not accurately reflect the status of diabetic neuropathy. More recently, analysis of alterations in the corneal nerves has emerged as a promising surrogate marker for diabetic peripheral neuropathy. In this review, we will discuss the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy, elaborating on the foundational aspects of each: pathogenesis, clinical presentation, evaluation, and management. We will further discuss the relevance of diabetic corneal neuropathy in detecting the presence of diabetic peripheral neuropathy, particularly early diabetic peripheral neuropathy; the correlation between the severity of diabetic corneal neuropathy and that of diabetic peripheral neuropathy; and the role of diabetic corneal neuropathy in the stratification of complications of diabetic peripheral neuropathy.
机标关键词：
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 2172-2178 )
英文信息