N-methyl-D-aspartate receptorfunctions altered by neuronal PTP1B activation in Alzheimer 's disease and schizophrenia models
Alexandre F.R.Stewart1
Hsiao-Huei Chen2
1.Department of Biochemistry,Microbiology and Immunology,University of Ottawa,and University of Ottawa Heart Institute,Ottawa,ON,Canada2.Centre for Infection,Immunity and Inflammation,Ottawa,ON,Canada Medicine,Cellular and Molecular Medicine, University of Ottawa Brain and Mind Institute, Ottawa Hospital Research Institute,Ottawa,ON,Canada
摘要：Glutamate is the main excitatory neurotransmitter in the brain and binds to two major classes of receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and the N-methyl-D-aspartate (NMDA) receptors. Unlike AMPA receptors that are immediately activated by glutamate release, NMDA receptors are blocked by magnesium and can only be activated by glutamate after membrane depolarization. Thus, NMDA receptors are only activated after repeated AMPA receptor activation by glutamate. NMDA receptors are, for the most part, calcium-permeable channels.
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论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 2208-2210 )