Advancements in our understanding of circular and long non-coding RNAs in spinal cord injury
Yan Zhang1
Ho Jun Yun2
Yu Ji3
Eric Cosky2
Wen-Xiu Zhang1
Wei Han3
Yu-Chuan Ding2
1.Central Laboratory,Beijing Luhe Hospital,Capital Medical University,Beijing,China2.Department of Neurosurgery,Wayne State University School of Medicine,Detroit,MI,USA3.Central Laboratory,Beijing Luhe Hospital,Capital Medical University,Beijing,China;Department of General Surgery,Beijing Luhe Hospital,Capital Medical University,Beijing,China
摘要：Spinal cord injury (SCI), either from trauma or degenerative changes, can result in severe disability and impaired quality of life. Understanding the cellular processes and molecular mechanisms that underlie SCI is imperative to identifying molecular targets for potential therapy. Recent studies have shown that non-coding RNAs, including both long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), regulate various cellular processes in SCI. In this review, we will describe the changes in lncRNA and circRNA expression that occur after SCI and how these changes may be related to SCI progression. Current evidence for the roles of lncRNAs and circRNAs in neuronal cell death and glial cell activation will also be reviewed. Finally, the possibility that lncRNAs and circRNAs are novel modulators of SCI pathogenesis will be discussed.
机标关键词：longcordrnasadvancementscircularinjurynon-codingspinal
论文发表日期：2022-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 2399-2403 )
英文信息