The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline
Amsha S.Alsegiani
Zahoor A.Shah
Department of Medicinal and Biological Chemistry,College of Pharmacy and Pharmaceutical Sciences,University of Toledo,Toledo,OH,USA
摘要：Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential for a healthy body and aging, but dysbiosis could initiate many chronic diseases. Understanding the underlying mechanisms of gut microbiota alterations/dysbiosis will help identify biomarkers for aging-related chronic conditions. This review summarizes recent advances in microbiota-neurodegenerative disease research and will enhance our understanding of gut microbiota dysbiosis and its effects on brain aging.
机标关键词：cognitiveage-relatedalterationdeclineeuroinflammationinfluencemicrobiota
论文发表日期：2022-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 2407-2412 )
英文信息