Engineering cerebral folding in brain organoids
Glen Scott
Yu Huang
Biological Engineering, College of Engineering,Utah State University, Logan, UT, USA
摘要：Valuable implement to the animal neurological models: Neurological diseases remain the largest cause of death and disability. The discovery of effective therapies is chiefly hindered by the lack of realistic neurological models. Unlike other tissues, it is infeasible or unethical to access primary human neural samples in bulk. But animal models often fail to replicate the complex human-specific neuronal factors present in vivo. Conventional in vitro cultures lack native three-dimensional (3D) morphologies, polarity, and receptor expression, as well as tissue-level interactions (Jensen et al., 2018).
机标关键词：engineeringbraincerebralfoldingorganoids
论文发表日期：2022-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 2420-2422 )