The"mitochondrial stress responses":the"Dr.Jekyll and Mr.Hyde"of neuronal disorders
Simone Patergnani1
Giampaolo Morciano1
Marianna Carinci1
Sara Leo1
Paolo Pinton2
Alessandro Rimessi2
1.Department of Medical Sciences,Section of Experimental Medicine,Laboratory for Technologies of Advanced Therapies,University of Ferrara,Ferrara,Italy2.Department of Medical Sciences,Section of Experimental Medicine,Laboratory for Technologies of Advanced Therapies,University of Ferrara,Ferrara,Italy;Center of Research for Innovative Therapies in Cystic Fibrosis,University of Ferrara,Ferrara,Italy
摘要：Neuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions,such as oxidative and metabolic stress,protein folding or import defects,and mitochondrial DNA alteration.Cells engage in different coordinated responses to safeguard mitochondrial homeostasis.In this review,we will explore the contribution of mitochondrial stress responses that are activated by the organelle to perceive these dangerous conditions,keep them under control and rescue the physiological condition of nervous cells.In the sections to come,particular attention will be dedicated to analyzing how compensatory mitochondrial hyperfusion,mitophagy,mitochondrial unfolding protein response,and apoptosis impact human neuronal diseases.Finally,we will discuss the relevance of the new concept:the"mito-inflammation",a mitochondria-mediated inflammatory response that is recently found to cover a relevant role in the pathogenesis of diverse inflammatory-related diseases,including neuronal disorders.
机标关键词：stressdisordersdr.jekyllmitochondrialmr.hydeneuronalresponses
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 2563-2575 )
英文信息