The roles of microRNAs in spinal cord ischemia-reperfusion injury
Feng-Shou Chen
Xiang-Yi Tong
Bo Fang
Dan Wang
Xiao-Qian Li
Zai-Li Zhang
Department of Anesthesiology,the First Hospital of China Medical University,Shenyang,Liaoning Province,China
摘要：Spinal cord ischemia/reperfusion injury is a devastating medical disorder with poor prognosis that is associated with several pathophysiological conditions.However,multiple stimuli can trigger SCII,so the underlying mechanism of this pathology has not yet been fully established.MicroRNAs(miRNAs)are a class of non-coding RNAs that mediate a variety of nervous system diseases and regulate numerous physiological functions,including apoptosis,autophagy,inflammation,and blood-spinal cord barrier damage.miRNA expression profiles are known to be altered after spinal cord ischemia/reperfusion injury.Therefore,gaining a better understanding of the significant roles that miRNAs play in spinal cord ischemia/reperfusion injury could help develop potential preventive and therapeutic strategies for spinal cord ischemia/reperfusion injury.This review summarizes the current state of our knowledge about the relationship between miRNAs and spinal cord ischemia/reperfusion injury,as well as potential miRNAs that could be targeted to treat spinal cord ischemia/reperfusion injury.
机标关键词：micrornasischemiacordinjuryreperfusionrolesspinal
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 2593-2599 )
英文信息