Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection
Ling-Ping Cen1
Tsz Kin Ng2
Wai Kit Chu3
Chi Pui Pang4
1.Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong,Shantou,Guangdong Province,China2.Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong,Shantou,Guangdong Province,China;Shantou University Medical College,Shantou,Guangdong Province,China;Department of Ophthalmology and Visual Sciences,The Chinese University of Hong Kong,Hong Kong Special Administrative Region,China3.Department of Ophthalmology and Visual Sciences,The Chinese University of Hong Kong,Hong Kong Special Administrative Region,China4.Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong,Shantou,Guangdong Province,China;Department of Ophthalmology and Visual Sciences,The Chinese University of Hong Kong,Hong Kong Special Administrative Region,China
摘要：Both inflammation and anti-inflammation are involved in the protection of retinal cells.Antagonists of the hypothalamic growth hormone-releasing hormone receptor(GHRHR)have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs,some with systemic complications.Such effects are also found in ocular inflammatory and neurologic injury studies.In experimental models of mice and rats,both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental conditions.This review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.
机标关键词：receptorgrowthexperimentalhormoneinflammationneuroprotectionocularreleasing
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 2643-2648 )
英文信息