Adipose tissue, systematic inflammation, and neurodegenerative diseases
Ana Paula de A.Boleti1
Pedro Henrique de O.Cardoso1
Breno Emanuel F.Frihling1
Patrícia Souza e Silva1
Luiz Filipe R.N.de Moraes1
Ludovico Migliolo2
1.S-Inova Biotech,Programa de Pós-Gradua??o em Biotecnologia,Universidade Católica Dom Bosco,Campo Grande,MS,Brazil2.S-Inova Biotech,Programa de Pós-Gradua??o em Biotecnologia,Universidade Católica Dom Bosco,Campo Grande,MS,Brazil;Programa de Pós-Gradua??o em Biologia Celular e Molecular,Programa de Pós-Gradua??o em Bioquímica,Universidade Federal do Rio Grande do Norte,Natal,Brazil
摘要：Obesity is associated with several diseases, including mental health. Adipose tissue is distributed around the internal organs, acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the tissues. Excessive nutritional intake results in hypertrophy and proliferation of adipocytes, leading to local hypoxia in adipose tissue and changes in these adipokine releases. This leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory cytokines. The presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling, which can generate a neuroinflammatory process. In this review, we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive dysfunction. We also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain, particularly the hypothalamus and hippocampus, and that this is partially responsible for these negative cognitive outcomes. In addition, we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.
机标关键词：neurodtissueadiposedegenerativediseasesinflammationsystematic
论文发表日期：2023-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 38-46 )
英文信息