Gangliosides in nervous system development, regeneration, and pathologies
Juliana F.Vasques1
Renata Guedes de Jesus Gon?alves2
Almir Jord?o da Silva-Junior3
Robertta Silva Martins2
Fernanda Gubert4
Rosalia Mendez-Otero5
1.Instituto de Ciências Biomédicas,Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil;Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Rio de Janeiro,Brazil2.Instituto de Biofísica Carlos Chagas Filho,Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil;Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro,Rio de Janeiro,Brazil;Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Rio de Janeiro,Brazil3.Instituto de Biofísica Carlos Chagas Filho,Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil;Programa Rede NanoSaúde do Estado do Rio de Janeiro,Rio de Janeiro,Brazil;Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Rio de Janeiro,Brazil4.Instituto de Ciências Biomédicas,Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil;Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro,Rio de Janeiro,Brazil;Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Rio de Janeiro,Brazil5.Instituto de Biofísica Carlos Chagas Filho,Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil;Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro,Rio de Janeiro,Brazil;Programa Rede NanoSaúde do Estado do Rio de Janeiro,Rio de Janeiro,Brazil;Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Rio de Janeiro,Brazil
摘要：Gangliosides, sialic acid-containing sphingolipids, are major constituents of neuronal membranes. According to the number of sialic acids and the structure of the oligosaccharide chain, gangliosides can be classified as simple or complex and grouped in different ganglio-series. Hundreds of gangliosides have been identified in vertebrate cells, with different expression patterns during development and related to several physiological processes, especially in the nervous system. While GD3 and its O-acetylated form, 9acGD3, are highly expressed in early developmental stages, GM1, GD1a, GD1b, and GT1b are the most abundant ganglioside species in the mature nervous system. Mutations in enzymes involved in ganglioside metabolism can lead to the accumulation of specific species, a condition termed gangliosidosis and usually marked by severe neurological impairment. Changes in ganglioside levels have also been described in several neurodegenerative diseases, such as Alzheimer's and Parkinson's. In this review, we summarized recent information about the roles of GD3, 9acGD3, GM1, GD1a, GD1b, GT1b, and other ganglioside species in nervous system development and regeneration, as well as clinical trials evaluating possible therapeutic applications of these molecules.
机标关键词：developmentregenerationsystemgangliosidesnervouspathologies
论文发表日期：2023-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 81-86 )
英文信息