A potential new tool to enhance translational success rate in stroke research by backcrossing techniques in transgenic mice
Takayuki Nakagomi1
Hideaki Nishie2
Toshinori Sawano3
Akiko Nakano-Doi1
1.Institute for Advanced Medical Sciences,Hyogo College of Medicine,Hyogo,Japan;Department of Therapeutic Progress in Brain Diseases,Hyogo College of Medicine,Hyogo,Japan2.Institute for Advanced Medical Sciences,Hyogo College of Medicine,Hyogo,Japan3.Department of Biomedical Sciences,Ritsumeikan University,Shiga,Japan
摘要：Ischemic stroke is a leading disease of the central nervous system, frequently coupled to severe damage and dysfunction in patients. Animal models mimicking human stroke provide useful tools for studying the pathomechanisms (e.g., inflammation, neuroprotection, and neural regeneration), the treatment efficiency of various materials (e.g., bioactive molecules or drugs), and transplantation usefulness by various cell types [e.g., neural stem/progenitor cells (NSPCs), and mesenchymal or hematopoietic stem cells] under ischemic stroke.
机标关键词：transgenicresearchsuccessstrokeratemicebackcrossingenhance
论文发表日期：2023-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 107-108 )