Simulating traumatic brain injury in vitro: developing high throughput models to test biomaterial based therapies
Raja Haseeb Basit1
Jessica Wiseman2
Farhana Chowdhury3
Divya Maitreyi Chari4
1.Bradford Royal infirmary,Bradford,West Yorkshire,UK;Sheffield Institute for Translational Neuroscience,University of Sheffield,Sheffield,UK2.Sheffield Institute for Translational Neuroscience,University of Sheffield,Sheffield,UK;Neural Tissue Engineering Keele Group,School of Medicine,Keele University,Staffordshire,UK3.Labcorp Drug Development, Harrogate,UK;Neural Tissue Engineering Keele Group,School of Medicine,Keele University,Staffordshire,UK4.Neural Tissue Engineering Keele Group,School of Medicine,Keele University,Staffordshire,UK
摘要：Traumatic brain injuries are serious clinical incidents associated with some of the poorest outcomes in neurological practice. Coupled with the limited regenerative capacity of the brain, this has significant implications for patients, carers, and healthcare systems, and the requirement for life-long care in some cases. Clinical treatment currently focuses on limiting the initial neural damage with long- term care/support from multidisciplinary teams. Therapies targeting neuroprotection and neural regeneration are not currently available but are the focus of intensive research. Biomaterial-based interventions are gaining popularity for a range of applications including biomolecule and drug delivery, and to function as cellular scaffolds. Experimental investigations into the development of such novel therapeutics for traumatic brain injury will be critically underpinned by the availability of appropriate high throughput, facile, ethically viable, and pathomimetic biological model systems. This represents a significant challenge for researchers given the pathological complexity of traumatic brain injury. Specifically, there is a concerted post-injury response mounted by multiple neural cell types which includes microglial activation and astroglial scarring with the expression of a range of growth inhibitory molecules and cytokines in the lesion environment. Here, we review common models used for the study of traumatic brain injury (ranging from live animal models to in vitro systems), focusing on penetrating traumatic brain injury models. We discuss their relative advantages and drawbacks for the developmental testing of biomaterial-based therapies.
机标关键词：vitromodelsbraintesthighbasedbiomaterialdeveloping
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 289-292 )
英文信息