Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson's disease
Baptiste Texier1
Morgane Prime1
Djamaa Atamena2
Pascale Belenguer2
Marion Szelechowski1
1.Toulouse Institute for Infectious and Inflammatory Diseases(INFINITY),Université Toulouse,CNRS,Inserm,UPS,Toulouse,France2.Centre de Recherches sur la Cognition Animale(CRCA),Centre de Biologie Intégrative(CBI),Université de Toulouse,CNRS,UPS,Toulouse,France
摘要：By controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intracellular calcium fluxes, Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity. However, its expression and stability are strongly modified in response to cellular stresses, in particular upon altered oxidative conditions during neurodegeneration. Here, we report and discuss the abundant literature that has highlighted its contribution to the pathophysiology of Parkinson's disease, as well as its therapeutic and prognostic potential in this still incurable pathology.
机标关键词：involvementmortalinparkinsondiseasehspa9perspectivetherapeutic
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 293-298 )
英文信息