Synaptopathy in CHMP2B frontotemporal dementia highlights the synaptic vesicle cycle as a therapeutic target
Miranda Robbins1
Emma L.Clayton2
1.MRC Laboratory of Molecular Biology;Department of Zoology,University of Cambridge,Cambridge,UK2.UK Dementia Research Institute at King's College London;Department of Basic and Clinical Neuroscience,Institute of Psychiatry,Psychology and Neuroscience,King's College London,Maurice Wohl Clinical Neuroscience Institute,London,UK
摘要：Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are both devastating neurodegenerative conditions. Despite affecting different regions of the nervous system (FTD affecting primarily the frontal and temporal lobes, whilst ALS presents with motor neuron loss), there is significant overlap between these conditions in terms of genetics, pathology, and disease mechanisms, and they are therefore often grouped as a spectrum of symptoms under the heading FTD/ALS (Abramzon et al., 2020). Significantly, there is currently no cure for ALS or FTD.
机标关键词：chmp2bvesicletargetcycledementiafrontotemporalhighlightssynaptic
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 315-316 )