Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis
Christopher T.Rhodes1
Chin-Hsing Annie Lin2
1.Eunice Kennedy Shriver National Institute of Child Health and Human Development(NICHD),National Institutes of Health(NIH),Bethesda,MD,USA2.Department of Integrative Biology,University of Texas at San Antonio,San Antonio,TX,USA;University of Texas at San Antonio Neurosciences Institute,San Antonio,TX,USA
摘要：Mechanisms regulating neurogenesis involve broad and complex processes that represent intriguing therapeutic targets in the field of regenerative medicine.One influential factor guiding neural stem cell proliferation and cellular differentiation during neurogenesis are epigenetic mechanisms.We present an overview of epigenetic mechanisms including chromatin structure and histone modifications;and discuss novel roles of two histone modifiers,Ezh2 and Suv4-20h1/Suv4-20h2(collectively referred to as Suv4-20h),in neurodevelopment and neurogenesis.This review will focus on broadly reviewing epigenetic regulatory components,the roles of epigenetic components during neurogenesis,and potential applications in regenerative medicine.
机标关键词：erasroleltraaseshistoneneurogenesistransfer
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 469-473 )
英文信息