Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality
Yulia Mitiagin1
Ari Barzilai2
1.Department of Neurobiology,the School of Neurobiology,Biophysics,Molecular Biology and Biochemistry,George S.Wise,Faculty of Life Sciences,Tel Aviv University,Tel Aviv,Israel2.Department of Neurobiology,the School of Neurobiology,Biophysics,Molecular Biology and Biochemistry,George S.Wise,Faculty of Life Sciences,Tel Aviv University,Tel Aviv,Israel;Sagol School of Neurosciences,Tel Aviv University,Tel Aviv,Israel
摘要：Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions.However,the functions of ataxia-telangiectasia mutated that when lost lead to cerebellar degeneration are still unknown.In this review,we first describe the role of ataxia-telangiectasia mutated in cerebellar pathology.In addition to its canonical nuclear functions in DNA damage response circuits,ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular homeostasis.We discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox state.Finally,we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons,astrocytes,and microglial cells.
机标关键词：integrityroleataxiacerebellarfunctionalityimportantmutatedplays
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 497-502 )
英文信息