Melatonin:a multitasking indoleamine to modulate hippocampal neurogenesis
Alejandro Romero1
José ángel Morales-García2
Eva Ramos1
1.Department of Pharmacology and Toxicology,Faculty of Veterinary Medicine,Complutense University of Madrid2.Institute for Biomedical Research"A.Sols"(CSIC-UAM);Spanish Center for Networked Biomedical Research on Neurodegenerative Diseases(CIBERNED);Department of Cellular Biology,School of Medicine,Complutense University of Madrid,Madrid,Spain
摘要：Neurodegeneration affects a large number of cell types including neurons,astrocytes or oligodendrocytes,and neural stem cells.Neural stem cells can generate new neuronal populations through proliferation,migration,and differentiation.This neurogenic potential may be a relevant factor to fight neurodegeneration and aging.In the last years,we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal neurogenesis.The lack of therapeutic strategies targeting neurogenesis led researchers to explore new molecules.Numerous preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in neurogenesis.We made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration,to summarize the current knowledge and highlight the therapeutic potential of melatonin.
机标关键词：melatoninhippocampalindoleaminemodulatemultitaskingneurogenesis
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 503-505 )
英文信息