Ferroptosis:a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury
Qing-Sheng Li1
Yan-Jie Jia2
1.Department of Neurology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,China;Academy of Medical Sciences,Zhengzhou University,Zhengzhou,Henan Province,China2.Department of Neurology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,China
摘要：Ferroptosis,a new non-necrotizing programmed cell death(PCD),is driven by iron-dependent phospholipid peroxidation.Ferroptosis plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation,immunity,and chronic injuries.The inhibitors against ferroptosis effectively improve iron homeostasis,lipid metabolism,redox stabilization,neuronal remodeling,and functional recovery after trauma.In this review,we elaborate on the latest molecular mechanisms of ferroptosis,emphasize its role in secondary central nervous trauma,and update the medicines used to suppress ferroptosis following injuries.
机标关键词：ferroptosisplayertargetbraincordcriticalinjurypotential
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 506-512 )
英文信息