Choroid plexus imaging to track neuroinflammation-a translational model for mouse and human studies
Muthuraman Muthuraman1
Mohammadsaleh Oshaghi1
Vinzenz Fleischer1
Dumitru Ciolac1
Ahmed Othman2
Sven G.Meuth3
Gabriel Gonzalez-Escamilla1
Sergiu Groppa1
1.Department of Neurology,Focus Program Translational Neuroscience,Rhine Main Neuroscience Network(rmn2),University Medical Center of the Johannes Gutenberg University Mainz,Mainz,Germany2.Department of Neuroradiology,University Medical Center of the Johannes Gutenberg University Mainz,Mainz,Germany3.Department of Neurology,Medical Faculty,Heinrich-Heine-University,Düsseldorf,Germany
摘要：The choroid plexus(ChP)is a highly vascularized and secretory tissue in each of the brain ventricles that represents the key structure between the blood and the cerebrospinal fluid(CSF).Besides its essential role in CSF production and brain waste clearance pathways,the ChP also contributes to the regulation of central nervous system(CNS)immunosurveillance(Ghersi-Egea et al.,2018).Indeed,the ChP forming the blood-CSF barrier(BCSFB)regulates the entry of immune cells and solute molecules into the brain and vice versa.When antigen-specific,autoreactive immune activation occurs in the periphery,inflammatory cells migrate through the brain barriers towards the CNS(Strominger et al.,2018),initiating neuroinflammatory diseases such as multiple sclerosis(MS).
机标关键词：imagingstudiestrackplexushumanmousemodelchoroid
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 521-522 )