Striatum-specific mechanisms regulate neuronal cell cycle re-entry:the choice between life and death
Paula Dietrich
Ioannis Dragatsis
Department of Physiology,The University of Tennessee,Health Science Center,Memphis,TN,USA
摘要：Mitochondria dysfunction occurs in the aging brain as well as in several neurodegenerative disorders and predisposes neuronal cells to enhanced sensitivity to neurotoxins.In particular,defects in any of the mitochondria respiratory chain complexes lead to impaired adenosine triphosphate production resulting in diseases that often affect the central nervous system.For instance,innate deficits in succinate dehydrogenase(SDH)mitochondria respiratory chain complex Ⅱ activity caused by genetic mutations in SDH subunits lead to early-onset neurodegeneration(Jain-Ghai et al.,2013),while several adult-onset genetic neurodegenerative disorders are associated with variable levels of complex Ⅱ deficiency in the central nervous system(Tunez et al.,2010).Also,chemically induced complex Ⅱ deficiency leads to neurodegeneration.
机标关键词：specificbetweencyclecelllifechoicedeathmechanisms
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 523-524 )