Developmental exposure to thyroid disruptors:misprogramming of the brain's stem cells in later life?
Pieter Vancamp
Sylvie Remaud
Laboratory of Molecular Physiology and Adaptation,CNRS UMR 7221,Department Adaptations of Life,Muséum National d'Histoire Naturelle,Paris,France
摘要：Introduction:Ever since the discovery of neural stem cells(NSCs)in the adult mammalian brain,scientists have been trying to decipher which signals govern their turnover and lineage commitment to generate neurons and glia.Understanding their role in nervous tissue homeostasis can provide new insights into the etiology of several neurological disorders,and might one day be turned to our advantage to promote endogenous brain injury repair.Others and we have identified thyroid hormone(TH)as a key factor transcriptionally regulating NSC behavior in the largest niche of the adult mammalian brain:the subventricular zone(SVZ).
机标关键词：exposurestemcellsbrainlifedevelopmentaldisruptorslater
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 527-528 )