Treating peripheral nerve injury-induced spinal cord degeneration and neuropathic pain with peripherally administrated stem cells
Zihui Wang1
Xiaofeng Jia2
1.Department of Neurosurgery,University of Maryland School of Medicine,Baltimore,MD,USA2.Department of Neurosurgery,University of Maryland School of Medicine,Baltimore,MD,USA;Department of Orthopedics,Anatomy and Neurobiology,University of Maryland School of Medicine;Department of Biomedical Engineering,Anesthesiology and Critical Care Medicine,Johns Hopkins University School of Medicine,Baltimore,MD,USA
摘要：Peripheral nerve injury(PNI)causes sensory and motor deficits as well as neuropathic pain,which seriously impacts patient quality of life(Jiang et al.,2017).Morphological and molecular changes in the spinal cord and dorsal root ganglia(DRG),such as neuronal cell death,nerve fiber degeneration,and glial activation,are strongly associated with PNI-induced pathological syndromes,such as sensitization and abnormal responses to peripheral stimuli and dysregulation of spinal cord circuitry(Calvo and Bennett,2012;Duraikannu et al.,2019:Zhang et al.,2021).
机标关键词：stemcellscordwithadministrateddegenerationinjury-inducednerve
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 537-538 )