Targeting neuroinflammation in Alzheimer 's disease: from mechanisms to clinical applications
Zi-Zhen Si1
Chen-Jun Zou2
Xi Mei3
Xiao-Fang Li4
Hu Luo4
Yao Shen5
Jun Hu2
Xing-Xing Li3
Lun Wu6
Yu Liu7
1.Pharmacy Department,The Affiliated Hospital of Medical School,Ningbo University,Ningbo,Zhejiang Province,China;Department of Physiology and Pharmacology,School of Medicine,Ningbo University,Ningbo,Zhejiang Province,China2.Department of Geriatric Psychiatry,Ningbo Kangning Hospital,Ningbo,Zhejiang Province,China3.Key Laboratory Office of Sleep Medicine,Ningbo Kangning Hospital,Ningbo,Zhejiang Province,China4.Department of Psychology,Collage of Teacher Education,Ningbo University,Ningbo,Zhejiang Province,China5.Department of Preventive Medicine,School of Medicine,Ningbo University,Ningbo,Zhejiang Province,China6.Pharmacy Department,The Affiliated Hospital of Medical School,Ningbo University,Ningbo,Zhejiang Province,China7.Department of Physiology and Pharmacology,School of Medicine,Ningbo University,Ningbo,Zhejiang Province,China
摘要：Alzheimer's disease is characterized by sustained neuroinflammation leading to memory loss and cognitive decline. The past decade has witnessed tremendous efforts in Alzheimer's disease research; however, no effective treatment is available to prevent disease progression. An increasing body of evidence suggests that neuroinflammation plays an important role in Alzheimer's disease pathogenesis, alongside the classical pathological hallmarks such as misfolded and aggregated proteins (e.g., amyloid-beta and tau). Firstly, this review summarized the clinical and pathological characteristics of Alzheimer's disease. Secondly, we outlined key aspects of glial cell-associated inflammation in Alzheimer's disease pathogenesis and provided the latest evidence on the roles of microglia and astrocytes in Alzheimer's disease pathology. Then, we revealed the double-edged nature of inflammatory cytokines and inflammasomes in Alzheimer's disease. In addition, the potential therapeutic roles of innate immunity and neuroinflammation for Alzheimer's disease were also discussed through these mechanisms. In the final section, the remaining key problems according to the current research status were discussed.
机标关键词：applicationsalzheimerclinicalfromdiseaseeuroinflammationmechanisms
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 708-715 )
英文信息