MicroRNAs: protective regulators for neuron growth and development
Zhi-Xuan Ma1
Zhen Liu2
Hui-Hui Xiong2
Zong-Pu Zhou1
Li-Si Ouyang2
Fu-Kang Xie2
Ya-Mei Tang3
Zhong-Dao Wu4
Ying Feng1
1.School of Medicine,South China University of Technology,Guangzhou,Guangdong Province,China2.Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong Province,China3.Department of Neurology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China4.Key Laboratory of Tropical Disease Control,Ministry of Education,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong Province,China
摘要：MicroRNAs (miRNAs) play an important regulatory role in neuronal growth and development. Different miRNAs target different genes to protect neurons in different ways, such as by avoiding apoptosis, preventing degeneration mediated by conditional mediators, preventing neuronal loss, weakening certain neurotoxic mechanisms, avoiding damage to neurons, and reducing inflammatory damage to them. The high expression of miRNAs in the brain has significantly facilitated their development as protective targets for therapy, including neuroprotection and neuronal recovery. miRNA is indispensable to the growth and development of neurons, and in turn, is beneficial for the development of the brain and checking the progression of various diseases of the nervous system. It can thus be used as an important therapeutic target for models of various diseases. This review provides an introduction to the protective effects of miRNA on neurons in case of different diseases or damage models, and then provides reference values and reflections on the relevant treatments for the benefit of future research in the area.
机标关键词：micrornasdevelopmentneurongrowthprotectiveregulators
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 734-745 )
英文信息