In vivo astrocyte-to-neuron reprogramming for central nervous system regeneration: a narrative review
Zuliyaer Talifu1
Jia-Yi Liu2
Yun-Zhu Pan1
Han Ke2
Chun-Jia Zhang2
Xin Xu2
Feng Gao2
Yan Yu3
Liang-Jie Du2
Jian-Jun Li1
1.School of Rehabilitation,Capital Medical University,Beijing,China;Department of Spinal and Neural Functional Reconstruction,China Rehabilitation Research Center,Beijing,China;Chinese Institute of Rehabilitation Science,Beijing,China;Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing,China;Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing,China;School of Rehabilitation Sciences and Engineering,University of Health and Rehabilitation Sciences,Qingdao,Shandong Province,China2.School of Rehabilitation,Capital Medical University,Beijing,China;Department of Spinal and Neural Functional Reconstruction,China Rehabilitation Research Center,Beijing,China;Chinese Institute of Rehabilitation Science,Beijing,China;Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing,China;Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing,China3.School of Rehabilitation,Capital Medical University,Beijing,China;Chinese Institute of Rehabilitation Science,Beijing,China;Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing,China;Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing,China
摘要：The inability of damaged neurons to regenerate within the mature central nervous system (CNS) is a significant neuroscientific challenge. Astrocytes are an essential component of the CNS and participate in many physiological processes including blood-brain barrier formation, axon growth regulation, neuronal support, and higher cognitive functions such as memory. Recent reprogramming studies have confirmed that astrocytes in the mature CNS can be transformed into functional neurons. Building on in vitro work, many studies have demonstrated that astrocytes can be transformed into neurons in different disease models to replace damaged or lost cells. However, many findings in this field are controversial, as the source of new neurons has been questioned. This review summarizes progress in reprogramming astrocytes into neurons in vivo in animal models of spinal cord injury, brain injury, Huntington's disease, Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions.
机标关键词：regenerationcentralreviewneuronsystemvivoastrocytenarrative
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 750-755 )
英文信息